منابع مشابه
p53 and MDM2: their Yin-Yang intimacy.
Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA E-mail: [email protected] The philosophy of Yin (阴) and Yang (阳) formed in ancient China describes a subtle, complementary, and sometimes intimate relationship between two opposites. This thousands of years old philosophy is, however, perfectly suited to descri...
متن کاملYin Yang 1 Is a Negative Regulator of p53
Yin Yang 1 (YY1) is a transcription factor that plays an essential role in development. However, the full spectrum of YY1's functions and mechanism of action remains unclear. We find that YY1 ablation results in p53 accumulation due to a reduction of p53 ubiquitination in vivo. Conversely, YY1 overexpression stimulates p53 ubiquitination and degradation. Significantly, recombinant YY1 is suffic...
متن کاملYin yang
oxidative Medicine and celluar Longevity 227 Derived from classical Chinese philosophy and with frequent applications in Chinese medicine, " yin yang " has grown into an interesting concept that may have a number of applications. The term is usually used to depict the existence of polarizing or opposing forces in nature. Yet, the concept of " yin yang " can be much more involved, especially in ...
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In this issue of Blood, Boulaftali and colleagues have made the important and novel observation that deficiency of the serine protease inhibitor (serpin), PN-1, in platelets results in a prothrombotic state, supporting the role of platelet PN-1 in thrombosis.1 Specifically, Boulaftali et al have initially confirmed previously published studies by Gronke et al indicating that protease nexin-1 (P...
متن کاملEnterococci: yin - yang microbes
This review deals with the duality of enterococci, which can be illustrated by their yin yang behaviour. The rough nature of this specific group of lactic acid bacteria promotes their dissemination in various environments where they significantly influence the outcome of a certain process. In the technological meaning, enterococci are leading microbes in fermentation processes of traditional fo...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2017
ISSN: 1759-4685
DOI: 10.1093/jmcb/mjx003